This is a Phase 1, open-label, dose de-escalation study designed to refine the existing ETEC H10407 human challenge model. The study is being carried out at the Johns Hopkins Bloomberg School of Public Health. Subjects will be recruited over a 60-day screening window, to be followed by the ETEC H10407 challenge, 28 days of safety and immunology follow-up, and a three month follow-up phone call. Subjects will be inpatient for about 8-9 days.
C-TASC’s services were acquired to assist in form configuration within StudyCTMS and support of data abstraction as requested by the Johns Hopkins study statistician.